• Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3·6 million adults in the UK 

      Bhaskaran, Krishnan; dos-Santos-Silva, Isabel; Leon, David A.; Douglas, Ian J.; Smeeth, Liam (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-30)
      <i>Background</i>: BMI is known to be strongly associated with all-cause mortality, but few studies have been large enough to reliably examine associations between BMI and a comprehensive range of cause-specific mortality outcomes.<p> <p><i>Methods</i>: In this population-based cohort study, we used UK primary care data from the Clinical Practice Research Datalink (CPRD) linked to national ...
    • Factors associated with excess all-cause mortality in the first wave of the COVID-19 pandemic in the UK: A time series analysis using the Clinical Practice Research Datalink 

      Strongman, Helen; Carreira, Helena; De Stavola, Bianca L.; Bhaskaran, Krishnan; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-06)
      Background: Excess mortality captures the total effect of the Coronavirus Disease 2019 (COVID-19) pandemic on mortality and is not affected by misspecification of cause of death. We aimed to describe how health and demographic factors were associated with excess mortality during, compared to before, the pandemic. <p> <p>Methods and findings: We analysed a time series dataset including 9,635,613 ...
    • Mortality among Care Home Residents in England during the first and second waves of the COVID-19 pandemic: an observational study of 4.3 million adults over the age of 65 

      Schultze, Anna; Nightingale, Emily; Evans, David; Hulme, William; Rosello, Alicia; Bates, Chris; Cockburn, Jonathan; MacKenna, Brian; Curtis, Helen J; Morton, Caroline E; Croker, Richard; Bacon, Seb; McDonald, Helen I; Rentsch, Christopher T; Bhaskaran, Krishnan; Mathur, Rohini; Tomlinson, Laurie A; Williamson, Elizabeth J; Forbes, Harriet; Tazare, John; Grint, Daniel; Walker, Alex J; Inglesby, Peter; DeVito, Nicholas J; Mehrkar, Amir; Hickman, George; Davy, Simon; Ward, Tom; Fisher, Louis; Green, Amelia CA; Wing, Kevin; Wong, Angel YS; McManus, Robert; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen JW; Douglas, Ian J; Smeeth, Liam; Eggo, Rosalind M; Goldacre, Ben; Leon, David A (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-10)
      Background Residents in care homes have been severely impacted by COVID-19. We describe trends in the mortality risk among residents of care homes compared to private homes. Methods On behalf of NHS England we used OpenSAFELY-TPP to calculate monthly age-standardised risks of death due to all causes and COVID-19 among adults aged >=65 years between 1/2/2019 and 31/03/2021. Care home residents ...